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KMID : 0378019740170020209
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New Medical Journal
1974 Volume.17 No. 2 p.209 ~ p.217
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Histological Findings of Lymphnodes in Patients with Psoriasis and Atopic Dermatitis
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李惟信/Lee, Yoo Shin
金忠相/金源錫/Kim, Choong Sang/Kim, Won Suk
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Abstract
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With the well known dermatopathic lymphadenitis, there have been many reports of lymphnode
findings on various dermatoses, but these were only descriptive or morphologic records by histopathologists. With advances in knowledge of lymphnode structures in the past 10 years, as a result of correlation between lymphnode changes and immunologic function, the lymphnode findings of various diseases must wait new interpretation.
The present study was undertaken to evaluate Iymphnode findings of the well-known immunological dermatoses, atopic dermatitis and psoriasis, especially in regard to immune functional aspects.
Five patients with atopic dermatitis and nine with psoriaisis and one with Zumbusch type of psoriasis were selected at Seoul National University Hospital. These patients were found to have no concomittant systemic disorder, determined by physical examination, CBC, urinalysis and chest X-ray film.
Inguinal lymphnodes were totally biopsied and routinely prepared for H-E staining. Histological examination was performed and special attention was paid to the changes noted in germinal centers, lymphocyte follicles, cortical areas, medullary cords (thymus independent areas), paracortical areas(thymus dependent areas) and sinuses. The results were as follows: 1. Lymphode findings in atopic dermatitis patients.
The thymus independent areas were well preserved in all cases and showed signs of immunologic hyperfunction. Thymus dependent areas revealed marked decrease in size and cellularity in four cases.
Sinuses were generally dilated and filled with massive reticulohistiocytes. 2. Lymphnode findings in psoriasis patients.
The thymus independent areas showed slight or marked depletion of lymphoid structures and cellularity in about half of cases. Thymus dependent areas were generally intact, but in four cases, slight or marked depletion of cellularity was noted. One case of Zumbusch type of psoriasis showed marked depletion of both thymus dependent and independent areas and replacement by reticulohistio
cytes throughout the entire nodal structure. Nine cases showed slight or moderate degree of sinus Lstiocytosis.
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